Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS.
Shearer GM, Pinto LA, Clerici M
Immunol Today 1999 Feb;20(2):66-71
Recent studies have demonstrated protective effects of alloimmunization in the SIV model. Here, Gene Shearer, Ligia Pinto and Mario Clerici raise the possibility that alloimmunization against a spectrum of HLA-disparate leukocytes be considered for immune-based therapy and as an AIDS vaccine.